Reengineering paramyxovirus tropism

Envelope targeting: hemagglutinin attachment specificity rather than fusion protein cleavage-activation restricts Tupaia paramyxovirus tropism.

To engineer a targeting envelope for gene and oncolytic vector delivery, we characterized and modified the envelope proteins of Tupaia paramyxovirus (TPMV), a relative of the morbilli- and henipaviruses that neither infects humans nor has cross-reactive relatives that infect humans. We completed the TPMV genomic sequence and noted that the predicted fusion (F) protein cleavage-activation site i...

Reengineering the Industrial CMMI

Abstract of Re-engineering of Industrial CMMI Through this research, I have established a general strategy to appraise an organization against a scale of five process maturity levels whilst maintaining a strong mechanics of CMMI. Reengineering of industrial CMMI proposes a novel method for Industrial Competence ranking of those organizations/companies which are targeting various CMM...

A Novel Paramyxovirus?

In public databases, we identified sequences reported as human genes expressed in kidney mesangial cells. The similarity of these genes to paramyxovirus matrix, fusion, and phosphoprotein genes suggests that they are derived from a novel paramyxovirus. These genes are sufficiently unique to suggest the existence of a novel paramyxovirus genus.

Viral Tropism

The authors in this Research Topic have highlighted the importance of viral tropism by presenting biological phenomena and their underpinning host cellular and molecular bases. The biologically unique phenomenon of viral tropism is not only of interest to virologists to bring progress to their basic science but also highly relevant to clinical studies with the goal to design new anti-viral stra...

Paramyxovirus disease in racing pigeons